FIG 5.
Antibodies provide 100% protection against challenge when administered prophylactically. Mice received a single intraperitoneal injection of antibody 24 h prior to challenge with 100 MLD50s of A/Vietnam/1203/04 (H5N1) administered intranasally, which caused 100% mortality in untreated mice within 10 days of infection (B, D, and F). BF1-19 provided 100%, 80%, and 0% protection against challenge when it was delivered at dosages of 2.5, 1, and 0.1 mg/kg, respectively (A and B). h10C3 provided 80% protection against challenge when it was delivered as a single 2.5-mg/kg dose (C and D), while FcDART provided 100% protection against challenge when it was delivered as a single 2.5-mg/kg dose 24 h before challenge (E and F). (A, C, and E) Data represent the mean percentage of the starting weight ± standard error of the mean for each mouse group (n = 5 mice per group). **, P < 0.01.