FIG 6.

Antibodies provided 100% protection against challenge when administered at 2.5 mg/kg at 24 h postchallenge. Mice received a single intraperitoneal dose of antibody at 2.5 mg/kg 24 or 72 h after challenge with 100 MLD₅₀s of A/Vietnam/1203/04 (H5N1) administered intranasally, which caused 100% mortality in untreated mice within 10 days of infection (B, D, and F). BF1-19 (A and B), h10C3 (C and D), and FcDART (E and F) provided 100% protection against challenge when administered at 24 h postchallenge. BF1-19 and h10C3 provided 80% protection against challenge when administered at 72 h postchallenge (B and D, respectively); however, FcDART provided 100% protection at 72 h postchallenge (F). (A, C, and E) Data represent the mean percentage of the starting weight ± standard error of the mean for each mouse group (n = 5 mice per group). hpi, hours postinfection; **, P < 0.01.