FIG 7.
BF1-19 provides 100% protection against challenge by A/Vietnam/1203/04 (H5N1) in ferrets. BF1-19 was administered to ferrets as a single 1-mg/kg dose intraperitoneally at 24 h postchallenge with 3 × 104 EID50s of A/Vietnam/1203/04 (H5N1), which caused 100% mortality in ferrets injected with PBS but no mortality in ferrets that were injected with BF1-19 (A). Ferrets that were injected with BF1-19 also exhibited less weight loss and lower temperatures than ferrets injected with PBS (B and C, respectively); however, these differences were not significant. Three ferrets were administered BF1-19, and two ferrets were administered PBS. *, P < 0.05.