FIG 8.

BF1-19 provides 100% protection against challenge from the antigenically drifted strain A/Whooper swan/Mongolia/244/05 (H5N1). A single 2.5-mg/ml intraperitoneal dose of BF1-19 administered at 24 h pre- or postchallenge provided 100% protection against challenge with 100 MLD₅₀s of A/Whooper swan/Mongolia/244/05 (H5N1). When this dose of antibody was administered at 72 h postchallenge, 80% protection was observed (A and B). (A) Data represent the mean percentage of the starting weight ± standard error of the mean for each mouse group (n = 5 mice per group). *, P < 0.05; **, P < 0.01.