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. 2015 Feb 11;89(8):4668–4675. doi: 10.1128/JVI.03455-14

FIG 4.

FIG 4

Inhibition of STAT-5 suppresses Tip60-dependent activation of the ATM DNA damage response. (A) RT-PCR analysis of Tip60 mRNA levels in CIN612 cells in the presence or absence of pimozide (10 μM) for the times (in hours) indicated beneath the bars. (B) Western blot analysis of Tip60, p-Tip60, and GAPDH protein levels of CIN612 cells for the times (in hours) indicated beneath the blots. (C) Western blot analysis for p-STAT-5, STAT-5, p-Tip60, Tip60, and GAPDH levels in cells positive for HPV31, HPV31 E5 KO, HPV31 E6, and HPV31 E6E7 grown in monolayer cultures. (D) Western blot analysis for p-Tip60, Tip60, and GAPDH levels in CIN612 cells treated with erlotinib at different concentrations for the various times (in hours) indicated beneath the blots. All results are representative of observations from 3 independent experiments.