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The BFA-resistant phenotype is cell type dependent in cells of human origin. A replicon assay with the wt and the DM BFA-resistant mutant (G4361A + C5190T) in 293 (human embryonic kidney) and SH-S5Y5 (human neuroblastoma) cell lines was performed. The total replication (area under the curve) was normalized to the replication of each replicon in the control samples containing equivalent amounts of DMSO solvent. P values are shown. ns, not significant.
