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Human DAF on intestinal epithelium does not enhance the susceptibility of IFNAR-KO mice to oral infection. IFNAR-KO mice and IFNAR-KO mice expressing the hDAF transgene were exposed to CVB3 H3-RD by gavage (106 to 108 PFU), and virus titers in tissues were determined at 3 days postinfection. (A) 1 × 106 PFU; (B) 1 × 107 PFU; (C) 1 × 108 PFU. Titers obtained in individual animals are shown, with mean titers indicated as bars. SI, small intestine; P, pancreas; L, liver; H, heart.
