FIG 4.

SIV-specific effector CD4 T cells exhibit a direct antiviral effect and are susceptible to infection during virus suppression. (A) Flow cytometry plots demonstrating CTV labeling differentiation between CTV⁻ CD4⁺ effectors and CTV CD4 targets in coculture are presented. (B and C) Flow cytometry analyses for SIV infection in untransduced CD4 T-cell clones and those expressing the CM9 TCR at days 5 and 7 postinfection are presented. Plots of gated cells are shown for CD4 staining on the y axis and SIV Gag staining on the x axis. (B) Flow cytometry analysis gated on targets. (C) Flow cytometry analysis gated on targets. Data presented are representative of five independent trials.