FIG 2.
Survival and disease manifestations in guinea pigs infected with rRomL/CanS, rCanL/RomS, and rRom expressing the F427I mutation in GP2 (rRom/G2F427I). (A) Hartley guinea pigs were inoculated i.p. with 103 PFU of rJUNVs (n = 3) and monitored for 21 days for survival. (B and C) Body temperature changes (B) and weight changes (C) were recorded throughout the course of the study. The range of normal guinea pig body temperature (37.2 to 39.5°C) is flanked by dashed lines on temperature graphs.