TABLE 1.
Hematology and blood chemistry parameters in guinea pigs infected with virulent and attenuated chimeric JUNV variants
| Groupb | Preinoculation/postinoculation valuesa |
||||
|---|---|---|---|---|---|
| Platelet count (103/ml) | White blood cell count (k/μl) | Lymphocyte count (k/μl) | Albumin (g/dl) | Alanine aminotransferase (U/liter) | |
| rRomero | 463 ± 122/40 ± 15 | 5.86 ± 1.7/1.82 ± 0.91 | 3.69 ± 0.76/0.75 ± 0.37 | 4.0 ± 0.1/3.0 ± 1.1 | 34 ± 9/79 ± 25 |
| rCanL/RomS | 465 ± 109/137 ± 70 | 4.79 ± 1.23/1.81 ± 0.56 | 3.33 ± 0.29/0.62 ± 0.24 | 4.1 ± 0.3/2.3 ± 0.1 | 30 ± 3/52 ± 15 |
| rRom/CanNP | 518 ± 188/164 ± 74 | 4.53 ± 0.79/1.87 ± 1.0 | 3.15 ± 0.29/0.62 ± 0.07 | 4.1 ± 0.3/2.3 ± 0.4 | 28 ± 1/46 ± 9 |
| rCandid #1 | 447 ± 110/464 ± 190 | 5.60 ± 1.5/6.14 ± 1.64 | 3.73 ± 1.22/4.48 ± 1.07 | 3.8 ± 0.0/4.0 ± 0.3 | 27 ± 6/33 ± 10 |
| rRomL/CanS | 493 ± 165/484 ± 124 | 5.29 ± 0.88/7.44 ± 1.61 | 3.38 ± 0.47/5.34 ± 1.89 | 4.2 ± 0.5/3.8 ± 0.4 | 30 ± 7/29 ± 8 |
| rRom/CanGPC | 447 ± 53/590 ± 103 | 5.01 ± 0.67/9.22 ± 4.17 | 3.22 ± 0.72/4.01 ± 1.14 | 4.6 ± 0.6/3.9 ± 0.2 | 30 ± 4/34 ± 6 |
| rRom/G2/F427I | 544 ± 107/528 ± 101 | 3.96 ± 0.6/6.41 ± 2.3 | 2.75 ± 0.64/4.81 ± 1.68 | 4.1 ± 0.2/3.8 ± 0.3 | 29 ± 5/32 ± 2 |
a
Blood was collected preinfection (day −7) and postinfection (day +12), and hematology and blood chemistry parameters were analyzed.
b
Hartley guinea pigs were inoculated i.p. with 103 PFU of rJUNVs.