TABLE 2.
Histopathological findings in tissues of guinea pigs infected with chimeric JUNV variants
| Virus groupa | Virulence for guinea pigs | Histological change(s)b |
|
|---|---|---|---|
| Spleen | Liver | ||
| rRomero, rCanL/RomS, rRom/CanNP | Yes | Congested and depleted red pulp; depleted, nonreactive white pulp; scattered macrophages and polymorphonuclear cells | Microvesicular and macrovesicular steatosis; periportal and lobular inflammation |
| rCandid #1, rRomL/CanS, rRom/CanGPC, rRom/G2/F427I | No | Unremarkable | Rare foci of periportal and lobular inflammation |
a
Guinea pigs were inoculated i.p. with 103 PFU of rJUNVs and euthanized at 12 days p.i. (dpi).
b
Histopathologic analysis was performed on H&E-stained tissue sections.