FIG 1.

Virological characterization of the reservoir in SIVsab-infected RM controllers. (a) Plasma viral load testing with a single-copy assay (SCA) (sensitivity, 1 copy/ml) demonstrates that in RM controllers with viral loads undetectable by conventional assays, virus control is consolidated during the follow-up, with the infection eventually becoming latent. dpi, days p.i. (b) During the latent stage of rhesus macaque infection, SIVsab mainly persists in memory CD4⁺ T-cell subsets. Ma, monocytes; EM, effector memory; CM, central memory; TM, transitional memory. (c) In the lymph nodes, similar to peripheral blood, virus control is consolidated during the follow-up.