FIG 2.

Rebounding SIVsab after CD8⁺ cell depletion in RM controllers is replication competent. Serial passage to naive RMs of pooled plasma collected from CD8⁺ cell-depleted RMs resulted in a productive infection which was indistinguishable from the infection with the original viral stock in terms of viral replication (a), peripheral (b) and mucosal (c) CD4⁺ T-cell depletion, changes in the frequency of naive (d) and memory (e) CD4⁺ T cells in the periphery, and immune activation (f, g) and proliferation (h, i) levels of CD4⁺ and CD8⁺ T cells, respectively.