FIG 1.
Schematic illustration of HIV-1 gp41 and peptide fusion inhibitors. The gp41 numbering of HIV-1HXB2 is used. FP, fusion peptide; NHR, N-terminal heptad repeat; CHR, C-terminal heptad repeat; TM, transmembrane domain. The sequences corresponding to the T20-resistant site are highlighted in bold, the sequences corresponding to the NHR pocket region are shown in blue, and the sequences corresponding to the CHR pocket-binding domain (PBD) are shown in red. The position and sequence of the M-T hook structure are shown in green. The peptide inhibitors and their sequences are listed, while the E49K substitution in the N peptide N36 and the N126K substitution in the C peptide C34 are highlighted in green.