Table 3.

p204-interacting proteins.

Proteins bound by p204	Effects of the binding of p204	Reference
UBF-1 ribosomal RNA transcription factor	Inhibition of the binding of UBF-1 to DNA and of ribosomal RNA transcription	[30]
pRb, p107, p130 pocket proteins	p204-pRb complex is a coactivator of the Cbfal transcription factor. Effects on cell cycling remain to be explored	[39,42]
Id1, Id2, Id3 inhibitors of differentiation and of DNA binding	p204 sequesters the Id proteins, promotes their translocation from the nucleus to the cytoplasm, and their ubiquitination and degradation by proteasomes. Thereby, p204 overcomes the inhibition by Ids of their target proteins	[35,38,40]
Tpr nuclear pore component	Binding of Tpr is likely to facilitate the translocation of p204 between the nucleus and the cytoplasm	[115]
H-Ras and K-Ras signaling proteins; their mutants include oncoproteins	p204 binding to the H-RasGTP and K-RasGTP (wild-type or oncoprotein) complexes inhibits the binding to the complexes of several Ras mediators and, thereby, blocks signaling	[58]
Sin3a involved in promoting histone deacetylation by HDAC	Effect of p204 binding remains to be explored	Liu and Lengyel (unpublished data)