TABLE 1.
Amino acid changes that differentiate H3N2 CIV from AIVs
| Segment | Positiona | AIV residue (%) | H3N2 CIV residue(s) (%)b | H3N8 CIV residue(s) (%)b |
|---|---|---|---|---|
| PB2 | 76 | T(96.5) | M(93.6)/I(17.4) | T(100) |
| 147 | I(78) | T(100) | V(100) | |
| 365 | M(97) | I(100) | M(100) | |
| 570 | M(94) | V(100) | M(100) | |
| PB1 | 108 | L(96) | I(100) | L(100) |
| 361 | S(94) | N(100) | S(100) | |
| 377 | D(97) | N(78.3)/D(21.7) | D(100) | |
| 517 | I(96) | V(95.64)/I(4.34) | I(100) | |
| 723 | R(97) | Q(93.6)/R(17.4) | R(100) | |
| 744 | M(94) | V(100) | M(100) | |
| PA | 65 | S(93) | Y(100) | S(100) |
| 208 | T(93) | A(100) | T(100) | |
| 234 | D(98) | N(83.3)/D(16.7) | D(100) | |
| 347 | D(99) | N(29.2)/D(70.8) | D(100) | |
| 369 | A(96) | V(100) | A(100) | |
| 441 | M(93) | K(87.5)/R(12.5) | M(95.1)/I(4.9) | |
| 615 | K(94) | R(100) | K(100) | |
| HA | 10 | T(95) | A(100) | T(100) |
| 81 | D(74) | N(100) | Y(98.75)/H(1.25) | |
| 111 | L(96) | I(83.3)/V(16.7)* | I(100) | |
| 172 | D(95) | N(100) | E(8.75)/K(91.25) | |
| 222 | W(90) | L(100)* | L(100) | |
| 435 | H(96) | N(91.7)/H(4.15)/K(4.15) | H(100) | |
| 489 | D(92) | N(100) | Y(100) | |
| NP | 52 | Y(58) | H(95.8)/Y(4.2)* | H(69.8)/Y(30.2) |
| 109 | I(97) | I(62.5)/V(37.5) | I(100) | |
| 125 | N(95) | G(91.7)/N(8.4) | N(100) | |
| 159 | M(95) | L(91.7)/M(8.4) | M(100) | |
| 373 | T(50) | K(95.8)/T(4.2) | T(100) | |
| 428 | A(94) | T(95.8)/A(4.2) | A(100) | |
| 452 | R(79) | K(95.8)/R(4.2)* | K(100) | |
| 473 | N(93) | K(95.8)/N(4.2) | N(100) | |
| NA | 24 | M(95) | L(100) | N/A |
| 48 | N(80) | S(91.7)/N(8.3) | N/A | |
| 54 | E(89) | K(100) | N/A | |
| 81 | P(74) | S(100) | N/A | |
| 143 | D(62) | N(100) | N/A | |
| 156 | P(96) | S(100) | N/A | |
| 372 | S(95) | L(100) | N/A | |
| 432 | R(96) | G(100) | N/A | |
| NS1 | 60 | A(87) | I(100) | A(99.46)/T(0.54) |
| 67 | R(91) | W(100) | Q(100) | |
| 75 | E(85) | K(100) | E(100) | |
| 152 | E(67) | N(100) | E(99.46)/D(0.54) | |
| 172 | E(95) | K(100) | E(100) |
a
Codon position. H3 numbering is used for codon positions in HA.
b
Amino acid present at the consensus level. The percentage of each amino acid in our data sets is shown in parentheses. Fixed mutations are shown in bold type. Asterisks indicate convergent mutations between H3N2 and H3N8 CIVs. N/A, not available.