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. 2015 Mar 4;89(10):5330–5339. doi: 10.1128/JVI.00020-15

FIG 3.

FIG 3

Correlation between CD8+ T cell responses restricted by each HLA and pVL or CD4 count. Epitope-specific CD8+ T cell responses at a peptide concentration of 100 nM were analyzed by using the ELISPOT assay. (A) Correlations between breadths of HLA-B*52:01-, HLA-B*67:01-, HLA-A*02:06-, or HLA-B*40:06-restricted CD8+ T cell responses and pVL in the individuals carrying each HLA. Five HLA-B*52:01-restricted (GagMI8/QA11/RI8/WV8/PolSI8), 3 HLA-B*67:01-restricted (GagEM11/TL9/NL11), 2 HLA-A*02:06-restricted (GagAA9/PolSV9), and 2 HLA-B*40:06-restricted (PolLA9/IT10) CD8+ T cell responses were analyzed. The values in each graph represent medians of pVL. (B) Correlations between total magnitudes of these HLA allele-restricted CD8+ T cell responses and pVL in individuals carrying the corresponding HLA. Correlations between the breadths or the magnitudes and pVL or CD4 count were statistically analyzed using Pearson's correlation coefficient test and the Spearman rank correlation test, respectively. Multiple tests were performed by using the q value. A significance threshold for q of <0.2 was employed.