TABLE 3.

EBNA3 amino acids under positive selection

Gene	Codon	No. of methodsa	Amino acid(s)		Location within known epitope
			Reference	Alternate
EBNA3A	54	2	H	Q, P	No
	459	3	P	T, S, R	458–466, YPLHEQHGM
	681	3	V	A, M	No
	814	3	G	V, A, D, T	No
EBNA3B	33	2	T	Q, K	No
	212	3	T	M, L, R	No
	417	2	V	L	416–424, IVTDFSVIK
	424	2	K	N, R	416–424, IVTDFSVIK
	488	3	A	T, R	488–496, AVLLHEESM
	553	3	P	L, H	No
	614	3	R	W, Q, L, P	No
	738	2	R	Q	No
	847	3	A	E	No
	887	2	A	P, G, V	No
	899	3	G	S	No
	900	3	Q	K, R	No
EBNA3C	104	3	T	A, P	No
	215	2	A	G, E	No
	357	2	G	V, I	No

^aPositive-selection detection methods used were FEL, MEME, and Fubar using the HyPhy package.