FIG 7.

EXT1 and GAGs are involved in infection by infectious MARV and EBOV. (a) Knockdown expression of EXT1 by siRNAs reduced levels of infection by infectious MARV and EBOV. The EXT1 siRNAs were introduced to A549 cells, and their effects on infection of infectious MARV and EBOV were determined following a protocol as described in Materials and Methods. An NT siRNA was used as the control in this experiment. Error bars represent standard deviations. (b) Effects of different GAGs on blocking infectious MARV infection. Different GAGs, at different concentrations, were mixed with infectious MARV, and their effects on blocking MARV infection on A549 cells were evaluated. Error bars represent standard deviations. (c) Effects of different GAGs on blocking infectious EBOV infection. Error bars represent standard deviations.