TABLE 2.

Maximum inhibitory activity (E_max) observed at different time points in different assays for telaprevir and AT23708

Drug and assay	Emaxa (%)
	12 h	24 h	48 h	72 h
Telaprevir
GLuc assay	16.67 ± 3.08	80.83 ± 2.09	99.01 ± 0.28	99.94 ± 0.02
NS5B reduction by Western blotting	34.29 ± 6.18	84.99 ± 7.61	100 ± 0.01	100 ± 0.27
Virus production by FFU assay	100 ± 0.01	100 ± 0.01	100 ± 0.01	100 ± 0.01
AT23708
GLuc assay	19.16 ± 3.10	38.06 ± 3.39	89.99 ± 2.87	99.54 ± 0.39
NS5B reduction by Western blotting	27.92 ± 0.97	48.39 ± 2.24	77.64 ± 1.45	100 ± 0.44
Virus production by FFU assay	99.89 ± 0.07	100 ± 0.01	99.71 ± 0.26	100 ± 0.01

^aData represent the mean ± standard error of the mean E_max values from ≥3 experiments.