TABLE 4.
Inhibitor | EC50 (nM) |
EC90 (nM) |
||||||
---|---|---|---|---|---|---|---|---|
12 h | 24 h | 48 h | 72 h | 12 h | 24 h | 48 h | 72 h | |
Telaprevir | 777 (686–880)a | 677 (626–733) | 765 (695–843) | 738 (566–962) | 2,778 (2,085–3,701) | 1,389 (1,180–1,635) | 1,255 (1,080–1,458) | 2,493 (1,333–4,664) |
AT23708 | 218 (200–237) | 91 (81–101) | 108 (97–121) | 123 (98–105) | 491 (413–583) | 428 (328–558) | 364 (285–466) | 294 (253–342) |
The values in parentheses are 95% confidence intervals.