TABLE 1.
Effects of SEVI treatment on the interaction of HIV with ectocervical and endocervical tissues from 12 human donors
| Parameter | Value for group |
|||||
|---|---|---|---|---|---|---|
| Ectocervix |
Endocervix |
|||||
| SEVI− | SEVI+ | P | SEVI− | SEVI+ | P | |
| Median total no. of virions (interquartile range)a | 198.5 (28.5, 235.5) | 93 (52, 109.5) | 0.26 | 49.5 (14, 123.5) | 35.5 (8.5, 68) | 0.72 |
| Total no. of virions/total no. of images (no. of virions/image) | 1,876/300 (6.25) | 1,204/300 (4.01) | 872/300 (2.91) | 477/300 (1.59) | ||
| Median no. of penetrators (interquartile range)a | 56.5 (17, 80.5) | 8.5 (4.5, 21) | 0.02 | 15 (9.5, 40.5) | 16.5 (7, 38) | 0.98 |
| No. of penetrators/total no. of images (no. of penetrators/image) | 615/300 (2.05) | 221/300 (0.737) | 417/300 (1.39) | 300/300 (1.00) | ||
| No. of penetrators/total no. of virions (%) | 615/1,876 (33) | 221/1,204 (18) | 417/872 (48) | 300/477 (63) | ||
| Prevalence ratio (SEVI+ vs SEVI−) (95% confidence interval)b | 0.56 (0.34, 0.91) | 0.02 | 1.32 (0.92, 1.89) | 0.14 | ||
| Avg penetration depth (μm)c | ||||||
| Including nonpenetrators | 1.55 | 1.05 | 0.001 | 5.65 | 10.08 | <0.0001 |
| Among penetrators | 4.72 | 5.74 | 0.08 | 11.81 | 16.03 | <0.0001 |
| No. of penetrators <15 μm/total no. of penetrators (%)d | 570/615 (93) | 196/221 (89) | 0.07 | 312/417 (75) | 185/300 (62) | 0.0002 |
| Max penetration depth (μm) | 48.7 | 41.5 | 66.7 | 63.1 | ||
a
Median numbers of virions (interquartile range) from all 12 donors. Exact Wilcoxon two-sample tests were performed to compare conditions without SEVI (SEVI−) to those with SEVI (SEVI+).
b
The prevalence ratio (95% confidence interval) and P value were estimated from log-binomial regression models using generalized estimating equations to adjust for repeated measures.
c
Average penetration depth per virion from all 12 donors. t tests were performed to compare conditions without SEVI to those with SEVI.
d
P values obtained by chi-square tests.