FIG 9.
Effect of H2S donor treatment on NiV-induced chemokine production and viral replication. SAE cells were infected with NiV at an MOI of 0.1 for 1 h, followed by treatment with a 5 mM concentration of GYY4137. (A) Cell supernatants from uninfected and NiV-infected cells, treated or untreated, were assayed at 24 h p.i. for cytokine and chemokine secretion by a Bio-Plex assay. Results are expressed as means ± standard errors. Results are representative of data from two independent experiments run in triplicate. *, P < 0.05 compared to untreated NiV-infected cells. (B) Viral replication was determined at 24 h postinfection by titration of viral infectious particles released into cell supernatants by a plaque assay. Results are representative of data from two independent experiments run in triplicate. *, P < 0.05 compared to untreated NiV-infected cells.