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Effect of CA mutations on drug susceptibility. The drug addition assay with PF74 (A and B), BI2 (C and D), or nevirapine (E and F) was performed over an extended time course with CA mutant viruses N74D, E45A, Q63/67A, A92E, and 5Mut. For each virus, data were normalized to the no-drug control. Shown are results from an average of three experiments, with error bars representing standard error of the mean.
