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Modeling of KIR3DS1 residues suggests a steric clash between R166 and HLA-Bw4 R83. Using the structure of KIR3DL1*001-HLA-B*57:01-LF9 for reference, the KIR3DS1-like R166 residue was modeled in place of the KIR3DL1 residue L166. HLA and peptide are shown in green and purple, respectively. KIR is shown in light blue (D1 residues), orange (D2 residues), and pink (D1-D2 loop). The presence of R166 in KIR3DS1 is predicted to cause both a steric and a charge clash with R83 in HLA-B57:01.
