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Acutely deleted Pten−/− cells respond poorly to IFN stimulation. Control PtenL/L and acutely deleted Pten−/− cells were pretreated with the indicated concentrations of IFN and then infected with rwt virus at an MOI of 10. Cell viability was determined by using an MTT assay at 72 h postinfection and is expressed as a percentage of mock-infected cells. *, P < 0.05.
