FIG 4.
Relative binding affinities of the viruses for 3′SLN versus SiaLex, SiaLec versus SiaLea, and 3′SLN versus SiaLec, determined Kaff(3′SLN)/Kaff(SiaLex), Kaff(SiaLec)/Kaff(SiaLea), and Kaff(3′SLN)/Kaff(SiaLec), respectively. Red indicates HPAIVs, and blue indicates LPAIVs. Differences in the ratio values of Kaff(3′SLN)/Kaff(SiaLex) between two groups of viruses, HPAIVs and LPAIVs, were statistically significant (P < 0.0001) and were determined using unpaired two-tailed t test. See Fig. 2 for virus abbreviations.