FIG 4.

Effect of ebv-miR-BART4-5p on Bid expression. (A) Sequence of putative binding site of ebv-miR-BART4-5p within 3′ UTR of BID mRNA. Mutations were introduced to the binding site. (B) Relative luciferase activity (Firefly/Renilla) in EBV-negative cells transfected with the wild-type BID 3′ UTR or mutant vectors and ebv-miR-BART4-5p or negative control. (C) Reduction rates of Bid expression in EBV-negative (no treatment) and -positive cells. Luciferase activities of the wild-type reporter are normalized to those of the mutant. NC, negative control; *, P < 0.05 (Student's t test); n.s., not statistically significant.