TABLE 2.
Functional clustering analysis of EBV miRNA target genes
| Database | Related pathway(s) | Gene count | P value |
|---|---|---|---|
| KEGG | Pathways in cancer | 37 | 0.0009 |
| KEGG | Focal adhesion | 31 | 0.0000 |
| KEGG | Regulation of actin cytoskeleton | 28 | 0.0005 |
| KEGG | Wnt signaling pathway | 25 | 0.0000 |
| KEGG | Ubiquitin mediated proteolysis | 20 | 0.0011 |
| KEGG | Axon guidance | 17 | 0.0080 |
| KEGG | Viral myocarditis | 16 | 0.0000 |
| KEGG | T cell receptor signaling pathway | 16 | 0.0035 |
| KEGG | Tight junction | 16 | 0.0240 |
| KEGG | Neurotrophin signaling pathway | 15 | 0.0270 |
| KEGG | Adherens junction | 14 | 0.0011 |
| KEGG | ECM-receptor interaction | 14 | 0.0025 |
| KEGG | ErbB signaling pathway | 13 | 0.0092 |
| KEGG | Dilated cardiomyopathy | 13 | 0.0140 |
| KEGG | Colorectal cancer | 12 | 0.0180 |
| KEGG | Hypertrophic cardiomyopathy | 12 | 0.0190 |
| KEGG | Fc gamma R-mediated phagocytosis | 12 | 0.0400 |
| KEGG | Pathogenic Escherichia coli infection | 11 | 0.0030 |
| KEGG | p53 signaling pathway | 11 | 0.0110 |
| KEGG | Arrhythmogenic right ventricular cardiomyopathy | 11 | 0.0230 |
| KEGG | Endometrial cancer | 10 | 0.0053 |
| KEGG | Acute myeloid leukemia | 10 | 0.0110 |
| KEGG | Dorsoventral axis formation | 8 | 0.0008 |
| KEGG | SNARE interactions in vesicular transport | 7 | 0.0330 |
| Reactome | REACT_604: hemostasis | 24 | 0.0058 |
| Reactome | REACT_16888: signaling by PDGF | 18 | <0.0001 |
| Reactome | REACT_11061: signaling by NGF | 17 | 0.0380 |
| Reactome | REACT_13552: integrin cell surface interactions | 15 | 0.0001 |
| Reactome | REACT_578: apoptosis | 14 | 0.0280 |
| Reactome | REACT_18266: axon guidance | 13 | <0.0001 |
| Reactome | REACT_11044: signaling by Rho GTPases | 13 | 0.0430 |
| Reactome | REACT_9417: signaling by EGFR | 11 | 0.0002 |
| Biocarta | Apoptotic signaling in response to DNA damage | 7 | 0.0180 |
| Biocarta | D4-GDI signaling pathway | 5 | 0.0340 |