FIG 4.

Identification of diversified B-cell/Ab epitopes. Continuous B-cell/Ab epitopes are indicated by solid bars; discontinuous B-cell/Ab epitopes are indicated by solid bars linked by dashed lines. Diversified sites identified from Fig. 3 are depicted as vertical bars. The B-cell/Ab epitopes containing sites experiencing diversifying selection in the evolution of the prepandemic H1N1 strains (diversified epitopes) are highlighted in blue or orange. Caton B-cell/Ab epitopes that contain diversified sites are highlighted in orange (Sa, Sb, and Ca2). B-cell/Ab epitopes that were not diversified are colored black.