FIG 5.

Diversified B-cell/Ab epitopes containing mutations acquired during pandemic evolution. All continuous and discontinuous diversified epitopes identified from Fig. 4 are shown. The 10 sites identified by meta-CATS analysis that have mutated since the 2009 outbreak are depicted as vertical bars. Meta-CATS sites that are located in the diversified B-cell/Ab epitopes identified in the prepandemic analysis are highlighted in red. Meta-CATS sites that are not located in any diversified B-cell/Ab epitope are highlighted in gray.