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. 2015 Mar 4;89(10):5427–5440. doi: 10.1128/JVI.03636-14

FIG 6.

FIG 6

Diversified B-cell/Ab epitopes highlighted on 3D HA trimer structure. Amino acid positions are highlighted on the A/California/04/2009 HA protein structure (PDB ID 3UBQ) based on the A/California/04/2009 full-length HA numbering. Nonoverlapping selected B-cell/Ab epitope positions are highlighted in blue, nonoverlapping positions found to be experiencing diversifying selection in the evolution of the prepandemic H1N1 strains are highlighted in red, nonoverlapping positions that have mutated between the early and late pandemic H1N1 strains are highlighted in yellow, prepandemic diversified sites that are located in the selected B-cell/Ab epitope are highlighted in purple, mutated pandemic sites that are located in the selected B-cell/Ab epitope are highlighted in green, and sites found to be under diversifying selection in the evolution of the prepandemic strains and mutated in the pandemic lineage are highlighted in orange. (A) Caton Sa epitope (see also Movie S1 in the supplemental material). (B) B-cell/Ab epitope IEDB:159269 (see also Movie S2). (C) Caton Sb epitope (see also Movie S3).