Table 1.

Subject Demographics, Loxapine Dosing, Weight, and Concomitant Medications

Sub_ID	Age	Race	Gender	End-point Loxa-pine dose mg/day	Wt. base-line (kg)	Wt. wk 6 (kg)	Wt. end (kg)	Baseline medications tapered off (weeks 1–6)	Concomitant medications constant dose (weeks 1–12)
1a	17	W	M	7.5	83.7	83.8	83.4	Escitalopram 20 mg daily	Clonidine 0.2 mg daily
2a	15	AA	M	7.5	68.0	68.9	66.3
3	26	W	M	15	139.0	139.0	137.6	Oxcarbazepine	Ezetimibe+simvastatin
4	24	W	M	2.5	94.6	n/a	94.4		melatonin 3–6 mg h.s., krill oil, minocycline 100 mg daily
5	27	W	F	5	77.3	78.9	79.2		Calcium, vitamin D, divalproex sodium125 mg (4 q.a.m.h.s.,3 q.noon)
6	39	W	M	10	75.7	77.2	77.2	Olanzapine 2.5 mg t.i.d.b
7	22	W	M	5	71.0	68.3	64.4	Mirtazapine 15 mg, aripiprazole 10 mg dailyb	Lamotrigine 100 b.i.d., amikacin 100 b.i.d.
8a	13	W	M	15	110.7	110.4	110.2		Loratadine daily OTC, fluticasone inhaler TT puffs daily, doxycycline
9	33	W	M	7.5	104.8	103.9	97.5	Risperidone 0.5 mL b.i.d.b	Escitalopram 15, lorazepam 1 mg a.m.,p.m., t.i.d.
10	24	W	F	10	82.2	80.3	79.4	Guanfacine1 mL t.i.d., divalproex sodium	Lamotrigine 100 q.a.m.
11a	16	W	M	10	71.7	71.2	71.2	Ziprasidone 20 mg b.i.d.b	Atomoxetine 25 mg b.i.d.
12a	13	AA	F	5	60.3	60.1	63.2	Dexmethylphenidate XR 20 mg, 10 mg noon, **quetiapine XR 150	Dexmethylphenidate IR 5 mg q 4 p.m., lorazepam melatonin 1 mg h.s.
13	26	W	M	10	70.8	73.0	74.8	Mixed amphetamine salts XR 30	Divalproex 1000 mg, trazodone100 h.s.
14	17	W	F	5	64.0	60.8	60.8	Olanzapine12.5 b.i.d.,b sertaline 25 mg	Naltrexone 50 daily, OCP
15	19	W	F	10	119.7	122.5	121.6	Ziprasidone 160 h.s.,blamotrigine 400 hs	Divalproex 1000
16a	16	W	M	10	66.0	69.2	68.1	Venlafaxine 50 daily	Sertraline 50 daily

^aAdolescents, n=6.

^bAtypical antipsychotics tapered and stopped, n=7.