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. Author manuscript; available in PMC: 2015 May 25.
Published in final edited form as: Acta Physiol (Oxf). 2015 Jan 8;213(3):628–641. doi: 10.1111/apha.12446

Figure 2.

Figure 2

Maximal responses in mean arterial blood pressure (MAP) to acute bolus application of INS45973 (P2Y2/4 agonist) in endothelial NO synthase knockout mice (eNOS−/−, n = 5). In eNOS−/− mice, application of INS45973 induced a dose-dependent, rapid decrease in blood pressure (left side, early phase). The dose-dependent rise in blood pressure above basal values following the initial decrease in eNOS−/− mice was significantly impaired compared to WT mice (right side, late phase). Some error bars are covered. *P < 0.05 vs. WT (two-way anova with repeated measures followed by Dunnett’s test).