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. Author manuscript; available in PMC: 2015 May 25.
Published in final edited form as: Acta Physiol (Oxf). 2015 Jan 8;213(3):628–641. doi: 10.1111/apha.12446

Figure 5.

Figure 5

Maximal responses in mean arterial blood pressure (MAP) to acute bolus application of INS45973 (P2Y2/4 agonist) in connexin 37 knockout mice (Cx37−/−, n = 5). In Cx37−/− mice, application of INS45973 induced a dose-dependent, rapid decrease in blood pressure (left side, early phase) which was significantly impaired compared to wild-type (WT) mice. The dose-dependent rise in blood pressure above basal values following the initial decrease in Cx37−/− mice was also significantly impaired compared to WT mice (right side, late phase). The dose-dependent blood pressure decrease in response to acetylcholine was comparable between Cx37−/− and WT mice and not followed by an acute blood pressure increase above basal values. Some error bars are covered. *P < 0.05 vs. WT (two-way anova with repeated measures followed by Dunnett’s test).