Table 1.
Potential miR regulators of p85α
| miR | Tumor vs. Benigna | Conserved Sitesb | p85α Correlationc |
|---|---|---|---|
| miR-21 | 1.42 | 2 | −0.09 |
| miR-617 | −1.13 | 1 | −0.46 |
| miR-525-5p | −0.94 | 1 | −0.45 |
| miR-936 | −1.52 | 1 | −0.43 |
| miR-488 | −3.97 | 1 | −0.41 |
| miR-519 | −0.37 | 1 | −0.40 |
| miR-635 | −1.28 | 1 | −0.40 |
| miR-486-5p | −0.40 | 1 | −0.38 |
| miR-634 | 0.24 | 1 | −0.34 |
| miR-127-5p | −0.84 | 1 | −0.26 |
| miR-498 | 0.71 | 1 | −0.25 |
| miR-656 | 0.96 | 1 | −0.24 |
| miR-650 | 0.03 | 1 | −0.24 |
| miR-1285 | 0.01 | 1 | −0.22 |
| miR-1229 | 1.02 | 1 | −0.21 |
| miR-554 | −0.31 | 1 | −0.17 |
| miR-548o | 0.45 | 1 | −0.16 |
| miR-330-3p | −0.53 | 1 | −0.14 |
| miR-455-3p | 0.50 | 1 | −0.14 |
| miR-767-5p | −1.40 | 1 | −0.10 |
| miR-495 | 0.38 | 1 | −0.06 |
| miR-221 | 1.01 | 1 | −0.05 |
| miR-15a | 0.23 | 1 | −0.01 |
| miR-548g | 0.19 | 1 | −0.01 |
a
Log-transformed p-value of Student’s T-test comparing expression in PDAC tumor cells vs. normal ductal epithelium based on miR array. A positive (negative) value indicates higher (lower) expression in tumor as compared to normal cells.
b
Number of predicted binding sites in p85α 3′UTR for each miR.
c
Correlation coefficient between miR and p85α (mRNA) expression levels in PDAC tumor cells.