Table 3.

Femoral trabecular micro-architecture in 10- and 21-week wild-type, trait, and sickle mice.

	10 Weeks			21 Weeks
Epiphysis	AA	AS	SS	AA	AS	SS
Tb. N. (1/mm)	8.725 (0.466)	8.68 (0.226)	8.687 (0.036)	8.094 (0.049)	8.058 (0.054)	8.015 (0.012)
Tb. Th. (mm)	0.054 (0.001)	0.055 (0.001)	0.051 (0.002)	0.055 (0.0004)	0.053 (0.001)	0.047a (0.001)
Conn.D. (1/mm3)	284.963 (9.315)	270.122 (19.998)	320.402 (32.517)	207.917d (4.716)	210.862d (8.478)	222.695d (16.21)
Tb. Sp. (mm)	0.125 (0.003)	0.117 (0.001)	0.12 (0.002)	0.129 (0.001)	0.131 (0.002)	0.132 (0.003)
SMI	0.418 (0.16)	0.304 (0.238)	0.85 (0.27)	0.356 (0.027)	0.577 (0.079)	1.121d (0.087)
TV (mm3)	0.558 (0.014)	0.589 (0.046)	0.589 (0.011)	0.572 (0.005)	0.574 (0.004)	0.639 (0.019)
BV (mm3)	0.181 (0.015)	0.201 (0.008)	0.179 (0.019)	0.179 (0.003)	0.163 (0.006)	0.139 (0.001)

Metaphysis	AA	AS	SS	AA	AS	SS
Tb. N. (1/mm)	7.072 (0.324)	7.011 (0.261)	7.143 (0.13)	5.064d (0.137)	4.275ad (0.242)	3.393ad (0.415)
Tb. Th. (mm)	0.058 (0.008)	0.051 (0.002)	0.052 (0.004)	0.05 (0.001)	0.048 (0.002)	0.037 (0.005)
Conn.D. (1/mm3)	274.196 (0.475)	308.618 (23.524)	314.778 (11.519)	139.526d (9.219)	95.544bd (9.819)	26.649ad (9.15)
Tb. Sp. (mm)	0.131 (0.009)	0.138 (0.008)	0.131 (0.005)	0.202d (0.005)	0.243bd (0.014)	0.302acd (0.034)
SMI	1.155 (0.507)	1.657 (0.211)	1.583 (0.254)	2.028 (0.078)	2.344 (0.135)	3.069acd (0.325)
TV (mm3)	1.216 (0.051)	1.35 (0.046)	1.245 (0.03)	1.389 (0.021)	1.373 (0.071)	1.556d (0.167)
BV (mm3)	0.355 (0.867)	0.325 (0.031)	0.324 (0.041)	0.171 (0.11)	0.156d (0.013)	0.066ad (0.014)

Data are presented as mean (SEM).

^aSignificance between wild-type and sickle (P < 0.05).

^bSignificance between wild-type and trait (P<0.05)

^cSignificance between trait and sickle (P < 0.05)

^dSignificance between age within genotype (P<0.05)