Table 4.
Femoral mechanical properties generated by four point bending in 10- and 21-weeks old wild-type (AA), trait (AS), and sickle (SS) mice.
| 10 Weeks |
21 Weeks |
|||||
|---|---|---|---|---|---|---|
| AA | AS | SS | AA | AS | SS | |
| Stiffness (N/mm) | 160.78 (29.16) | 151.8 (15.77) | 100.49ac (5.51) | 168.22 (12.69) | 155.67 (18.4) | 120.12ac (13.7) |
| Post yield Deflection (mm) | 0.147 (0.015) | 0.247b (0.042) | 0.299a (0.002) | 0.218 (0.041) | 0.279 (0.024) | 0.239 (0.085) |
| E (GPa) | 3.62 (0.33) | 4.05 (0.43) | 2.93ac (0.3) | 3.27 (0.26) | 4.56b (0.73) | 2.79ac (0.28) |
| Work (Nmm) | 5.13 (1.48) | 6.48 (1.85) | 5.19 (0.2) | 5.02 (1.35) | 5.92 (0.43) | 4.48 (0.73) |
| Max Force (N) | 26.4 (7.53) | 20.68 (2.03) | 17.05 (1.21) | 26.21 (3.57) | 22.4 (1.63) | 15.9ac (1.16) |
| Yield Force (N) | 19.12 (4.95) | 8.74 (1.01) | 10.71 (0.12) | 12.56 (0.81) | 12.79 (2.8) | 7.29ad (0.62) |
| Ultimate Stress (MPa) | 114.96 (23.14) | 103.75 (8.67) | 96.09 (8.75) | 116.85 (15.19) | 119.61 (5.32) | 78.39a (10.72) |
| Yield Stress (MPa) | 83.63 (14.84) | 44.64 (6.84) | 60.25 (2.14) | 50.42 (1.27) | 69.27 (16.64) | 35.26ad (1.27) |
Data are presented as mean (SEM).
a
Significance between wild-type and sickle (P < 0.05).
b
Significance between wild-type and trait (P<0.05)
c
Significance between trait and sickle (P < 0.05)
d
Significance between age within genotype (P<0.05)