Table 1. Incidence of TMDT-induced tonic-clonic seizures and lethality after post-treatment with Diazepam (DZP) or MK-801 monotherapy.
Fractions under “Clonic Seizures (n/N),” “Tonic Clonic Seizures,” and “Death.” indicate the number of mice (n) presenting with the phenomenon out of the total number of mice in the group (N); fractions under # indicate the total number of episodes (n) out of the total number of mice in the group (N). TMDT and treatments were administered ip.
| Group | Clonic Seizures | Tonic-clonic Seizures | One hour lethality | 24 hour lethality (cumulative) | |
|---|---|---|---|---|---|
| n/N | # | ||||
| Control (TMDT alone) | 19/19 | 49/19 | 19/19 | 19/19 | 19/19 |
| DZP 1 mg/kg | 4/5 | 27/5 | 5/5 | 3/5 | NA |
| DZP 2 mg/kg | 5/5 | 29/5 | 3/5 | 1/5 | 5/5 |
| DZP 3 mg/kg | 6/6 | 9/6 | 1/6 | 1/6 | 5/6 |
| DZP 5 mg/kg | 16/16 | 29/16 | 3/16 | 0/16 | 4/9 |
| DZP 7 mg/kg | 9/9 | 11/9 | 1/9 | 1/9 | 6/9 |
| DZP 9 mg/kg | 7/7 | 7/7 | 0/7 | 0/7 | 0/7 |
| DZP ED50 | 2.42±0.758 | 0.848±0.834 | 5.48±1.5 | ||
| MK801 0.2 mg/kg | 6/6 | 39/6 | 6/6 | 2/6 | 6/6 |
| MK801 0.3 mg/kg | 7/7 | 40/7 | 6/7 | 4/7 | 7/7 |
| MK801 0.5 mg/kg | 12/12 | 243/12 | 8/12 | 1/12 | 2/6 |
| MK801 0.7 mg/kg | 7/7 | 62/7 | 4/7 | 1/7 | 3/7 |
| MK801 1 mg/kg | 15/15 | 69/15 | 2/15 | 0/15 | 0/9 |
| MK-801 ED50 | 0.597±0.130 | 0.187 ± 0.145 | 0.504±0.085 | ||