Table 3. Incidence of TMDT-induced tonic-clonic seizures and lethality in mice post-treated with Diazepam-MK-801 binary mixtures.
Fractions (n/N) under “Clonic Seizures,” “Tonic-clonic Seizures” and “Death” indicate the number of mice (n) presenting with the phenomenon out of the total number of mice in the group (N); fractions under # indicate the total number of episodes (n) out of the total number of mice in the group (N). TMDT and treatments were administered ip.
| Treatment (mg/kg) | Clonic Seizures | Tonic-clonic Seizures | Cumulative Death (n/N) | |||
|---|---|---|---|---|---|---|
| n/N | # | n/N | # | one hour | 24 hour | |
| Control (TMDT alone) | 19/19 | 49/19 | 19/19 | 27/19 | 19/19 | 19/19 |
| DZP 0.36/MK-801 0.12 | 5/5 | 31/5 | 4/5 | 16/5 | 3/5 | 4/5 |
| DZP 0.48/MK-801 0.18 | 5/5 | 45/5 | 5/5 | 13/5 | 0/5 | 1/5 |
| DZP 0.72/MK-801 0.24 | 7/7 | 43/7 | 3/7 | 4/7 | 0/7 | 5/7 |
| DZP 1.05/MK-801 0.36 | 7/7 | 25/7 | 2/7 | 2/7 | 1/7 | 4/7 |
| DZP 1.2/MK-801 0.4 | 9/9 | 38/9 | 1/9 | 1/9 | 0/9 | 3/9 |
| DZP 1.44/MK-801 0.48 | 7/7 | 8/7 | 0/7 | 0/7 | 0/7 | 1/7 |
| DZP 1.2; MK-801 0.4 after 10 min | 9/9 | 13/9 | 0/9 | 0/9 | 0/9 | 0/9 |
| DZP 1.8/MK-801 0.16 (11:1) | 7/7 | 7/7 | 0/7 | 0/7 | 0/7 | 6/7 |