. Author manuscript; available in PMC: 2016 Jan 31.

Published in final edited form as: Pharmacogenomics J. 2014 Nov 25;15(4):310–315. doi: 10.1038/tpj.2014.69

Table 2.

Genetic variants of ADRA1A associated with sensitivity to phenylephrine (ED₅₀)

SNP	Caucasians				African Americans			All
	ED_50, ng/min, geometric mean (95% CI)			P-value^* unadjust. (adjusted)	ED_50, ng/min, geometric mean (95% CI)			P-value^* unadjust. (adjusted)	P-value^* unadjust. (adjusted)
	0^*	1	2	P-value^* unadjust. (adjusted)	0^*	1	2	P-value^* unadjust. (adjusted)	P-value^* unadjust. (adjusted)
rs574647	395 (248–627)	322 (201–514)	43 (5–360)	0.022 (0.064)	214 (131–350)	98 (46–208)	468	0.283 (0.039)	0.064 (0.008)
rs574647	N = 28	N = 32	N = 4	0.022 (0.064)	N = 29	N = 11	N = 1	0.283 (0.039)	0.064 (0.008)

rs1079078	244 (156–381)	365 (199–671)	963 (593– 1565)	0.030 (0.055)	139 (85–230)	329 (162–667)	201	0.094 (0.082)	0.003 (0.011)
rs1079078	N = 38	N = 21	N = 5	0.030 (0.055)	N = 29	N = 11	N = 1	0.094 (0.082)	0.003 (0.011)

rs13270252	269 (186–398)	646 (316–1318)	324	0.108 (0.039)	186 (112–302)	204 (87–490)	35 (4–331)	0.207 (0.027)	0.586 (0.686)
rs13270252	N = 53	N = 10	N = 1	0.108 (0.039)	N = 21	N=14	N = 3	0.207 (0.027)	0.586 (0.686)

rs580739	394 (245–632)	241 (140–414)	336 (77–1468)	0.360 (0.623)	267 (172–416)	55 (32–93)	468	0.007 (0.005)	0.131 (0.103)
rs580739	N = 29	N = 29	N = 6	0.360 (0.623)	N = 29	N = 11	N = 1	0.007 (0.005)	0.131 (0.103)

0, 1, 2 represent the number of variant alleles for each SNP.

N = number of subjects in each genotype group.

P values are before (unadjust.) and after adjustment for sex, BMI, baseline norepinephrine values and ethnicity (for analyses of the combined cohort).