Table 1. Postmortem finding in people with schizophrenia versus healthy controls among nicotinic receptors either from ligand binding studies or messenger RNA/proteins.

Reference	α7 Binding Ligand	α7 mRNA or Proteins	α4β2 Binding Ligand	α4β2 mRNA or Proteins
Freedman et al 1995	↓ Hipp		↓ Hipp
Leonard et al 1998	↓ Hipp		↓ Hipp*
Court et al 1999	↓ Thalamus		ND in many areas
Guan et al 1999	↓PFC, ND PC
Breese et al 2000 **			↓ Hipp, Thalamus, Cau
Court et al 2000			↑ Striatum
Durany et al 2000			↓ Striatum
Leonard et al 2001		↓ Hipp
Martutle et al 2001	↓ CC		↑ CC and OFC
Martin-Ruiz et al 2003		ND DLPFC	↑ DLPFC	ND DLPFC
De Luca et al 2006		ND DLPFC
Mathew et al 2007	ND DLPFC, Hipp	ND DLPFC and Hipp
Mexal et al 2010		↓ Hipp***
Thomsen et al 2011	ND Hipp

Cau = Caudate, CC = cingulate cortex, DLPFC = dorsal lateral prefrontal cortex, Hipp = hippocampus, OFC = orbital frontal cortex, PC = parietal cortex, PFC = Prefrontal cortex, →= decrease, ↓= increase ND = no difference

^*did not increase with nicotine use as seen in normal controls

^**all comparisons smoking controls versus schizophrenia smokers

^***Only in non-smokers with schizophrenia