Table 2. Nicotine administration studies in people with schizophrenia that measure cognition.

	Nicotine Ad- ministration	Dose (mg) or Administration	Duration	Design	Smokers	Antipsychotics	Enrolled	Cognitive Battery	Results of Nicotine (N) Compared to Placebo (P) or Con- trol (C) Condition
Levin 1996	Patch	7, 14, 21	4 days	Placebo Crossover	100%	Haloperidol (titrated to low, medium, and how doses)	15	ANAM (DMS, RT, SMT, SPRT), CPT	SPRT: N > P, DMS: N > P, CPT: N > P (On all tasks interaction with nicotine dose and haloperidol dose)
Smith 2002	Cigarettes/Nasal	3-6 cigarettes / 50% 6 sprays (L) 50% 12 sprays (H)	4 days	Placebo Crossover	100%	1^st and 2^nd Gen- eration	31	ANAM (DMS, RT, SMT, SPRT), RMT (5-items, DS, PW, SS), VF	SPRT: Cigarettes, Nasal > P RT: H Nasal > P PW, SS: Nasal > P
^*Sherr 2002	Nasal	2 sprays	2 days	Crossover	52%	1^st and 2^nd Gen- eration	29	CPT	N = C
^*Depatie 2002	Patch	14	2 days	Placebo Crossover	100%	1^st and 2^nd Generation	15	CPT	CPT: N > P
^*Myers 2004	Nasal	6 sprays	2 days	Crossover	52%	1^st and 2^nd Gen- eration	29	DMS, DRT	DRT: (Smokers) N > control
^*Jacobson 2004	Patch	28 or 35 Weight based	2 days	Placebo Crossover	100%	1^st and 2^nd Gen- eration	13	SAL, VWM	VWM: N > P
Harris 2004	Gum	6	2 days	Placebo Crossover	50%	1^st and 2^nd Gen- eration	20	RBANS	Attention: (Non- Smokers) N > control
Smith 2005	Nasal	8 sprays	4 days	Placebo Crossover	100%	1^st and 2^nd Gen- eration	27	ANAM (SPRT), CPT, DMT, RANDT MS	CPT, DMT: N > P
^*Barr 2007	Patch	14	2 days	Placebo Crossover	0%	1^st and 2^nd Gen- eration	28	CPT, GP, LNS, ST	CPT, ST: N > P
^*Jubelt 2008	Patch	14	2 days	Placebo Crossover	0%	1^st and 2^nd Gen- eration	10	EMP	EMP: N > P
^*Hong 2011	Patch	21 or 35 based on cigarette use	2 days	Placebo Crossover	100%	1^st and 2^nd Gen- eration	20	RVIP	RVIP: N > P
Hahn 2013	Cigarettes/Patch	Ad libitum/14	3 days	Placebo Crossover	100%	1^st and 2^nd Gen- eration	17	SARAT, SDT	SARAT: Patch > P SDT: Patch, Cigarettes > P

ANAM: Neuropsychological Assessment Metrics, CPT: Continuous Performance Test, CRT: Complex Reaction Time, DMS: Delayed Matching to Sample, DMT: Dot Memory Test, DRT: Delayed Recognition, DS: Digit Span, EMP: Episodic Memory Paradigm, GP: Grooved Pegboard, LNS: Letter Number Sequence, MS: Memory Scale, N: Nicotine, P: Placebo, PW: Paired Words, RBANS: Repeatable Battery for the Assessment of Neuropsychological Status, RMT: Randt Memory test, RT: Reaction Time, RVIP: Rapid Visual Information Processing, SAL: Selective Attention Load, SARAT: Spatial Attentional Resource Allocation Task, SDT: Singleton Detection Task, SMT: Sternberg Memory Test, SPRT: Spatial Rotation Task, SS: Short Story, ST: Stroop Test, VSWM: Visuospatial Working Memory, VWM: Verbal Working Memory, WCST: Wisconsin Card Sorting Test, WSPT: Word Serial Position Test

Healthy controls enrolled but results only on schizophrenia cohort