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. 2015 Jun;145(6):489–511. doi: 10.1085/jgp.201411281

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© 2015 Petrovič et al.

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Figure 3. — Simulation of calcium sparks with different activation site–related parameters of the RyR gating model. (A) Typical simulations for cytosolic [Ca²⁺] of 0.05 (top row) and 0.4 µM (bottom row) for (left to right) control, a threefold decrease of K_Ca, a threefold increase of K_Mg, a threefold decrease of f_Ca and f_Mg, and a twofold increase of p_dis. (B–G) The calcium dependence of the frequency of triggered sparks (Δϕ_Spark; B), the increase of the average number of open RyRs in triggered sparks $(Δ {\bar{n}}_{O};$ C), spontaneous spark frequency (ϕ_Spark; D), calcium sensitivity of spontaneous spark frequency (∂_Caϕ_Spark; E), average number of open RyRs in spontaneous sparks $({\bar{n}}_{O};$ F), and calcium sensitivity of the average number of open RyRs in spontaneous sparks $(\partial_{Ca} {\bar{n}}_{O};$ G) for control conditions (black symbols) and for decreased (red symbols) and increased (blue symbols) parameters K_Ca, K_Mg, f_Ca, p_dis, and f_Mg. The parameters were changed to 33 and 300% of control, except for p_dis that was changed to 50 and 200% of control. Theoretical predictions (D–G) and predictions of multiple linear regression (B and C) are shown by solid lines. Theoretical values and data from simulations at calcium concentrations used in the experiment (Lukyanenko and Gyorke, 1999) shown in Fig. 1 are shown as open and closed symbols, respectively. Error bars represent mean ± SEM.