Table 5.
Volumetric studies by magnetic resonance (MR) of cirrhotic patients with different grades of hepatic encephalopathy (HE).
| MR study | Subjects | n | Brain density or brain volume compared to control |
|
|---|---|---|---|---|
| Gray matter | White matter | |||
| (Guevara et al, 2011)a | Control | 51 | ||
| No HE | 48 | ↓ | ↓ | |
| (Zhang et al, 2012)b | Control | 40 | ||
| No HE | 31 | ↓c | ↑c | |
| MHE | 18 | ↓c | ↑c | |
| Overt HE | 11 | ↓c | ↑c | |
a
Voxel-based morphometry study of brain density.
b
Voxel-based morphometry study of brain volume.
c
Significant changes between cirrhotic patients without HE (no HE), with minimal HE (MHE) or with overt HE.