Fig. 7.

Hepatic response to ADs. LDLrKO mice were fed the indicated ADs for 16 weeks before the livers were harvested to measure lipid content and gene expression. A: Hepatic lipid content. Neutral lipid = CE + TG. B: Hepatic mRNA expression of genes involved in cholesterol biosynthesis, lipogenesis, and inflammation. C: Nuclear accumulation of mature SREBP-1c and -2 isoforms in liver. D: Hepatic FAS and SCD-1 protein content. Data are expressed as mean ± SEM, n = 5. Groups with different letters are significantly different (P < 0.05) by one-way ANOVA and Tukey’s post hoc analysis.