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. 2015 May 26;6:106. doi: 10.3389/fphar.2015.00106

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Copyright © 2015 Thiel, Platt, Wolf, Hatt and Gisselmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histamine action on GABA-induced currents of GABA_ARs with the point mutated β2(Y157F) subunit. (A,D) Original traces of the histamine (3 mM) action on the GABA-induced currents of the GABA_ARs α1β2(Y157F)γ2L and α1β2(Y157F). (B,C,E,F) Bar diagrams show the action of various histamine concentrations on the GABA-induced currents of the GABA_ARs α1β2(Y157F)γ2L, α1β2(Y157F), α1β2γ2L, and α1β2. Significant data were marked with ^∗p ≤ 0.05, ^∗∗p ≤ 0.01, and ^∗∗∗p ≤ 0.001.