Table 2.
Summary results of association between sporadic CRC patients’ smoking habit and several major molecular features
| Gene | No. of sudies | Effect model | OR (95% CI) | Heterogeneity | Publication bias (P value) | ||
|---|---|---|---|---|---|---|---|
|
|
|||||||
| I2 (%) | P | Begg’s test | Egger’s test | ||||
| APC mutation | 5 | Random | 0.79 (0.51-1.20) | 53.5 | 0.072 | 0.221 | 0.485 |
| APC methylation | 2 | Fixed | 0.94 (0.79-1.12) | 0 | 0.660 | N/A | N/A |
| KRAS mutation | 11 | Random | 1.17 (0.93-1.49) | 71.2 | 0 | 0.213 | 0.2 |
| P53 mutation | 6 | Fixed | 1.25 (1.07-1.45) | 9.4 | 0.356 | 0.452 | 0.453 |
| BRAF mutation | 6 | Random | 1.21 (0.89-1.64) | 67 | 0.010 | 1 | 0.783 |
| MSI | 10 | Fixed | 1.28 (1.12-1.47) | 0 | 0.855 | 1 | 0.711 |
N/A, not avaliable.