Table 3.
Subgroup analysis and sensitivity analysis of histological score
| Variables | Steatosis | Ballooning | Lobular inflammation | Fibrosis | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| No. of trials | Mean difference (95% CI) | P for heterogeneity | No. of trials | Mean difference (95% CI) | P for heterogeneity | No. of trials | Mean difference (95% CI) | P for heterogeneity | No. of trials | Mean difference (95% CI) | P for heterogeneity | |
| Vit.E dosage | ||||||||||||
| ≤ 800 mg/d | 0 | NA | NA | 0 | NA | NA | 0 | NA | NA | 1 | -0.25 (-0.72, 0.22) | NA |
| > 800 mg/d | 2 | -0.62 (-0.95, -0.29) | 0.76 | 2 | -0.30 (-0.56, -0.04) | 0.97 | 2 | -0.39 (-0.67, -0.11) | 0.80 | 2 | -0.44 (-0.90, 0.02) | 0.03 |
| Duration | ||||||||||||
| ≤ 24 week | 0 | NA | NA | 0 | NA | NA | 0 | NA | NA | 1 | -0.25 (-0.72, 0.22) | NA |
| > 24 week | 2 | -0.62 (-0.95, -0.29) | 0.76 | 2 | -0.30 (-0.56, -0.04) | 0.97 | 2 | -0.39 (-0.67, -0.11) | 0.80 | 2 | -0.44 (-0.90, 0.02) | 0.03 |
| Quality score | ||||||||||||
| ≥ 4 | 0 | NA | NA | 0 | NA | NA | 0 | NA | NA | 1 | -0.25 (-0.72, 0.22) | NA |
| < 4 | 2 | -0.62 (-0.95, -0.29) | 0.76 | 2 | -0.30 (-0.56, -0.04) | 0.97 | 2 | -0.39 (-0.67, -0.11) | 0.80 | 2 | -0.44 (-0.90, 0.02) | 0.03 |
| Sensitivity analysis | ||||||||||||
| Trials use vitE only as treatment | 1 | -0.60 (-0.95, -0.25) | NA | 1 | -0.30 (-0.57, -0.03) | NA | 1 | -0.40 (-0.69, -0.11) | NA | 1 | -0.20 (-0.50, 0.10) | NA |
VitE: vitamin E; NA: not applicable.