Table 1.
The characteristics of included studies in the meta-analysis
| First author | Year | Country | Ethnicity | Genotype-case | Genotype-control | Source of control | Genotype method | Cox-2 polymorphism | HWE test |
|---|---|---|---|---|---|---|---|---|---|
|
|
|
||||||||
| VR Ho/Ht/WT Ho* | VR Ho/Ht/WT Ho* | ||||||||
| Chang | 2013 | China | Chinese | 105/181/89 | 107/171/97 | hospital | PCR-RFLP | rs689466 | Y |
| 2013 | China | Chinese | 0/89/286 | 0/60/315 | hospital | PCR-RFLP | rs20417 | Y | |
| 2013 | China | Chinese | 0/127/248 | 0/117/258 | hospital | PCR-RFLP | rs5275 | N | |
| Gangwar | 2011 | India | Indian | 2/48/162 | 4/64/182 | hospital | PCR-RFLP | rs689466 | Y |
| 2011 | India | Indian | 4/80/128 | 12/61/177 | hospital | PCR-RFLP | rs20417 | N | |
| 2011 | India | Indian | 24/106/82 | 34/119/97 | hospital | PCR-RFLP | rs5275 | Y | |
| Srivastava | 2009 | India | Indian | 5/37/142 | 11/52/104 | population | PCR-RFLP | rs689466 | Y |
| 2009 | India | Indian | 8/45/131 | 8/32/127 | population | PCR-RFLP | rs20417 | N | |
| 2009 | India | Indian | 29/88/67 | 25/91/51 | population | PCR-RFLP | rs5275 | Y | |
| Song | 2008 | China | Chinese | 51/99/30 | 65/86/29 | hospital | PCR-RFLP | rs689466 | Y |
| 2008 | China | Chinese | 1/19/154 | 0/18/159 | hospital | PCR-RFLP | rs20417 | Y | |
| 2008 | China | Chinese | 4/39/132 | 5/61/113 | hospital | PCR-RFLP | rs5275 | Y | |
| Qin | 2014 | China | Chinese | 24/26/4 | 64/32/1 | hospital | Taqman | rs5275 | Y |
| Yang | 2008 | USA | American | 10/163/446 | 11/200/416 | population | SNPlex | rs20417 | N |
| 2008 | USA | American | 76/268/279 | 85/312/236 | population | SNPlex | rs5275 | Y |
*
VR, variant; WT, wild-type; Ht, heterozygote; VR Ho, variant homozygote; WT Ho, wide-type homozygote;
Y, in agreement with HWE; (Hardy-Weinberg equilibrium); N, in disagreement with HWE.